Prima Celiac Test Kit

Celiac disease, also known as “celiac sprue”, is an autoimmune disorder that involves the digestive process of the small intestine. It’s a chronic inflammatory disorder produced by the ingestion of dietary gluten products in susceptible people. It can have both environmental and hereditary factors: those who have celiac family members, in fact, are more likely to incur the disease during their lifetime. Celiac disease is defined as a permanent intolerance to gluten, a substance contained in wheat and composed of gliadin and glutenin. Gluten helps maintain food shape, acting like a glue that holds them together. Gliadin is the protein component of gluten, responsible for the immune system reaction, due to intestinal inflammation. In celiac subjects the immune system reacts against gluten damaging the intestinal wall, responsible for the absorption of nutrients. Cereals which contain gluten are: oats, wheat, barley, kamut, spelled, rye, spelled and triticale.

Unlike common Celiac Disease Screening tests, which detect only the presence of IgA antibodies, the PRIMA® Lab Celiac Test identifies anti-DGP antibodies of both class A and G. This because many subjects have an IgA deficiency, often unknown, which could lead to false results if the parameter detected is only the immunoglobulin A. Celiac Test is based on an immunochromatographic reaction: if the antibodies IgA and IgG are present into the sample, they will react with the deamidated gliadin and a red band will appear in the test area. A positive result indicates that the antibody concentration is close to the determined cut-off.