Creatine: The Most Researched Supplement

Creatine: The Most Researched Supplement

Whether you're a weekend warrior, a professional athlete, or simply interested in aging well, creatine deserves your attention. It’s one of the most studied and safest supplements on the market—and it’s not just for bodybuilders.

Here’s everything you need to know about creatine, with a focus on science-backed benefits, how it works, and why it may belong in your wellness routine.

🧬 What Is Creatine?

Creatine is a naturally occurring compound made from three amino acids: arginine, glycine, and methionine. It’s stored mostly in your muscles and acts as a rapid energy source during short bursts of intense activity.

You get some creatine from food (like red meat and fish), and your liver and kidneys make a small amount—but most people don’t consume enough through diet alone to reach optimal levels.

⚡️ How Creatine Works in the Body

Creatine’s main role is to recycle ATP (adenosine triphosphate)—your body’s primary energy currency. During high-intensity exercise, ATP runs out fast. Creatine helps regenerate it quickly, allowing you to push harder, lift heavier, and recover faster.

Key mechanism: Creatine phosphate donates a phosphate group to ADP to regenerate ATP.

🧪 Backed by Science: Key Benefits of Creatine

1. Improves Exercise Performance

Increases strength, power, and muscle endurance during resistance and sprint-based activities.

Meta-analysis (Branch, 2003; Rawson & Volek, 2003) shows creatine improves strength gains by 8–14% on average.

2. Supports Muscle Growth-

Creatine increases intramuscular water, creating a fuller appearance and triggering muscle protein synthesis.

Long-term use has been shown to enhance lean mass, especially in combination with resistance training (Buford et al., 2007).

3. Brain Health and Cognitive Function

Creatine isn’t just for muscles—your brain uses ATP too.

Research shows creatine can improve memory, mental fatigue, and cognitive performance, especially during sleep deprivation or intense stress (Rae et al., 2003; Avgerinos et al., 2018).

4. Neuroprotective Benefits

Studies suggest potential in supporting patients with Parkinson’s disease, depression, and traumatic brain injury by preserving brain energy metabolism (Andres et al., 2008; Bender et al., 2007).

5. Anti-Aging and Sarcopenia Prevention

In older adults, creatine may preserve muscle mass, strength, and function—important for independence and fall prevention (Candow et al., 2014).

🧂 How to Take Creatine: Dose and Timing

Standard dosage:

Loading phase (optional): 20g per day for 5–7 days, split into 4 doses

Maintenance: 3–5g daily long term

When: Any time of day is effective, but post-workout with a meal may slightly enhance absorption.

Best form:

Creatine Monohydrate – most researched, cost-effective, and well-absorbed.

Avoid fancy marketing claims about “new” forms unless backed by studies.

💦 Is Creatine Safe?

Yes. Creatine has been shown to be safe for long-term use in healthy individuals—even over periods of 5+ years.

📚 Safety studies: No evidence of kidney, liver, or cardiovascular damage in healthy populations (Poortmans & Francaux, 2000).

Side effects?

Mild water retention in the early weeks

Possible digestive upset if taken in large doses on an empty stomach

Drink plenty of water and stick to the recommended dose.

🌱 Is Creatine Suitable for Vegans and Vegetarians?

Absolutely—and they may benefit even more. Plant-based diets lack creatine-rich foods, so supplementing can improve muscle function and cognitive performance more significantly in this group (Rogerson, 2007).


🔬 Summary: Creatine At a Glance

Benefit Evidence Level Notes
Muscle strength & size 🔬🔬🔬🔬🔬 Highly supported
Exercise recovery 🔬🔬🔬🔬 Moderate support
Brain function 🔬🔬🔬 Growing interest
Anti-aging support 🔬🔬🔬 Great for 40+
Safety profile 🔬🔬🔬🔬🔬 Long-term proven

🛒 Where to Find High-Quality Creatine

At the Wellness Store, we stock pharmaceutical-grade creatine monohydrate from brands you can trust—free from fillers, tested for purity, and available in vegan-friendly options.

Not sure if creatine is right for your goals? Chat with our holistic pharmacist or in-store nutritionist for personalised advice.

📌 Final Word

Creatine isn’t a “muscle drug.” It’s an energy-boosting, brain-supporting, age-defying powerhouse backed by decades of science. Whether you’re an athlete, a student, a busy parent, or approaching midlife, creatine could be one of the simplest, safest upgrades to your daily routine.

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